An expeditious green synthesis of Schiff bases and azetidinones derivatised with 1,2,4-triazoles

Abstract

An efficient green approach to the synthesis of Schiff bases (11-21) of 1-amino-2-aryl-3-oxo-1,2,4- triazoles (1-3) have been reported under Mg(ClO 4)2 as catalyst followed by the reaction with chloroacetyl chloride in solvent-free conditions to yield the azetidinones (22-32) with excellent yields. The synthesized compounds were evaluated for the extent of penetration into biological membranes (clogP), drug-likeliness and finally drug score was calculated and also screened for antitubercular and antimicrobial activities. © Indian Academy of Sciences.