Michael addition reaction and its examples

Abstract

Michael addition reaction refers to the conjugate addition reaction of carbocation to , -unsaturated aldehydes, ketones, carboxylic acids, esters, nitrile, nitro compounds, etc. The reaction is an essential organic reaction, and it is used in organic synthesis to grow carbon chains and synthesize organic compounds with various functional groups. As one of the most valuable organic synthesis reactions, it is one of the most common ways to construct carbon-carbon bonds. This paper analyzes the mechanisms and the theories of some common Michael addition reactions. It also includes an example of the research of Michael addition in recent years. In a recent study, a research team experimentally found a suitable catalyst to catalyze the Michael addition reaction on benzyl groups, and obtained the different performances of benzyl groups with different functional groups during addition. Cyclopentadienyl rhodium catalyst has excellent catalytic activity and selectivity for benzyl first, second, and third C/H bonds. The reaction can be compatible with halogen, ester, and amide functional groups.