Regioselective synthesis and anti-inflammatory activity of novel dispiro[pyrazolidine-4,3′-pyrrolidine-2′,3″-indoline] -2″,3,5-triones

Abstract

Novel dispiro[pyrazolidine-4,3′-pyrrolidine-2′,3″- indoline]-2″,3,5-triones 5a-j were obtained regioselectively by 1,3-dipolar cycloaddition reaction of 4-arylidene-1-phenylpyrazolidine-3,5- diones 2a-e as dipolarophiles with non-stabilized azomethine ylides, generated in situ via decarboxylative condensation of isatins 3a,b and sarcosine 4 in dry ethanol. The prepared compounds were screened for their anti-inflammatory activity "at a dose of 10 mg/kg body weight", especially 5d, 5f, 5h, and 5j which reveal remarkable activities relative to indomethacin which was used as a reference standard in this study. © ARKAT-USA, Inc.