A high resolution bi-atrial optical mapping system for the analysis of arrhythmia in the hypertensive heart

Abstract

High resolution optical mapping of cardiac activation spread is a powerful tool for investigating the mechanisms of arrhythmia. However, due to the complex geometry of the atria, mapping global electrical activity is challenging. In this study, we present a high resolution optical mapping set-up and a data processing pipeline for characterising bi-atrial arrhythmia. Our system enables recording of bi-atrial electrical activity with high spatial and temporal resolution and provides a flexible tool for programming pacing protocols. Preliminary results indicate that this imaging system and data processing pipeline provide a reliable platform for experimental characterisation of bi-atrial arrhythmia.