The Wolff rearrangement of α-diazo carbonyl compounds has remained important in organic synthesis since its development more than 115 years ago. The risks involved in handling diazo compounds can be minimized by utilizing micro-flow technology. In addition, photochemical Wolff rearrangement can be carried out efficiently with the aid of micro-flow technology. Integrated micro-flow synthesis is therefore well-suited to the preparation of α-diazo carbonyl compounds and their photochemical Wolff rearrangement. This review article summarizes recently reported micro-flow photochemical Wolff rearrangements and their application in integrated micro-flow syntheses.
CITATION STYLE
Fuse, S., Otake, Y., & Nakamura, H. (2017, December 1). Integrated Micro-Flow Synthesis Based on Photochemical Wolff Rearrangement. European Journal of Organic Chemistry. Wiley-VCH Verlag. https://doi.org/10.1002/ejoc.201700789
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