BIOCHEMICAL EFFECT OF PARSEEK YAVANI AS PRE-ANESTHETIC AGENT IN RELATION TO KETAMINE ANESTHESIA

Abstract

There are many paths which lead to the acquisition of clinical knowledge that might profitably be explored, but there is only one high road to increase the therapeutic knowledge and that is the controlled clinical trial. The importance of clinical trial cannot be overlooked. This is the only way to confirm the experimental observations, claims made by previous workers and also to find out additional action and side effects, which are sometimes observed only in human beings. The drug Parseek Yavani (Hyocyamus niger) has been found to have analgesic, antisialagouge and sedative effects. So, the plan to study the trial drug as pre-anesthetic agent with special reference to its biochemical effect in relation to Ketamine anesthesia was taken up on patients according to American Society of Anesthesiologist Grade 1. Aims of present research work was to know the bio-chemical variation in the body after administration of research drug, to study the side effects of drug if any, to put forward an ideal and safe drug for pre-medication in Sangyaharana (Anesthesia) and to establish the efficacy of Ayurvedic drug in the field of pre-medication in Sangyaharana. The results of the study shown significant rise of Alkaline Phosphatase value (P < .001) before and after premedication in trial group as compared to standard group while other biochemical changes were insignificant.