Antimicrobial activity studies on some 1,2,4-triazine derivative in vitro.

Abstract

The antimicrobial activities of some 1,2,-4 triazines compounds were examined against Serratia marcescens W225, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumonia, Pseudomonas aeruginosa, Shigella spp., Candida albicans and Penicillium notatum. The antimicrobial activity of these compounds was found moderate to strong against the bacterial and fungal strains in vitro. Results indicated that compound (A) has a higher antimicrobial activity as compared with others. The mode of action of the new synthetic compounds on E. coli, B. subtilis, St. aureus, K. pneumonia and C. albicans showed morphological abnormalities and high rate of potassium leakage from the cells. It was concluded that these compounds had a deleterious effect on the flow of potassium. The protein profile of the previous organisms showed new protein band under the chemical stress.