T cell extracellular vesicles go nuclear to turn cold tumors hot

Abstract

In this issue of Cancer Cell, Hu et al. demonstrate that activated T cell extracellular vesicles (ATEVs)transfer genomic DNA into dendritic cells and tumor cells via granzyme B-mediated nuclear delivery, boosting antitumor immunity. Combined with PD-1 blockade, ATEVs synergistically overcome immune evasion in cold tumors, presenting a cell-free therapeutic strategy.