092 Physical performance is associated with self-reported and clinical osteoarthritis, but not radiographic osteoarthritis in both sexes

Abstract

Objectives: We have previously demonstrated relationships between self-reported and clinical hip and knee osteoarthritis (OA) and physical performance (PP) but not for a radiographic definition of OA. Here we extended this analysis to consider whether the relationships are the same in both sexes, and are similar for other comorbidities. Methods: Data were available for 222 men and 221 women who participated in the UK component of the European Project on Osteoarthritis (EPOSA). Participants completed a questionnaire detailing past medical history including self-reported OA and other comorbidities. Hip and knee radiographs were taken and graded for overall Kellgren and Lawrence (K & L) score, a positive definition reflecting a score of 2 or above. PP was determined from assessments of walking speed, chair stands and balance to create a composition score (0-12); low PP was defined as ≤9. Results: The mean (standard deviation (SD)) age of study participants was 75.5 (2.5) and 75.8 (2.6) years in men and women respectively. Self-reported hip or knee OA was associated with poor PP in men (OR 2.39, 95%CI 1.17, 4.87 p=0.016) and women (OR 2.66, 95%CI 1.24, 5.72 p=0.012). Similarly, a significant association was found between a clinical diagnosis of hip or knee OA and low PP in both men (OR 3.78, 95%CI 1.36, 10.49 p=0.011) and women (OR 4.08, 95%CI 1.37, 12.15 p=0.012). No significant relationships were observed between radiographic hip or knee OA and PP. Significant associations were also observed between low PP and hypertension in both men (OR 1.78, 95%CI 1.01, 3.11 p=0.044) and women (OR 2.09, 95%CI 1.10, 3.97 p=0.025). An association was found between low PP and heart disease (OR 2.39, 95%CI 1.17, 4.87 p=0.016) and diabetes (OR 2.47, 95%CI 1.05, 5.83 p=0.039) but in men only. Considering relationships with other comorbidities, no significant association was observed between low PP and osteoporosis, thyroid disease, depression, cancer, lung disease and stroke in both men and women. Conclusions: We have demonstrated a relationship between low PP and self-reported and clinical OA, but not radiological OA, in both men and women. Equivalent relationships were not observed with most other common comorbidities, suggesting mechanical joint factors may drive this association.