Abstract
Background: Epithelial to mesenchymal transition (EMT) correlates with increased metastatic potential and poor prognosis. Results: Secreted eHsp90 induces EMT, matrix metalloproteinase activity and cell motility. Conclusion: EMT inducing activity of eHsp90 provides a mechanistic basis for its tumorigenic and metastatic function. Significance: The requirement for eHsp90 in supporting tumorigenic events indicates that targeting eHsp90 may represent a therapeutic approach to improve prostate cancer patient survival. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Hance, M. W., Dole, K., Gopal, U., Bohonowych, J. E., Jezierska-Drutel, A., Neumann, C. A., … Isaacs, J. S. (2012). Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. Journal of Biological Chemistry, 287(45), 37732–37744. https://doi.org/10.1074/jbc.M112.389015
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