Therapeutic effects of microecological agents combined with metformin in type 2 diabetes mellitus with irritable bowel syndrome

Abstract

BACKGROUND In recent years, the role of intestinal flora in the occurrence and progression of irritable bowel syndrome (IBS) has been gradually recognized, and, as recommended agents for the treatment of IBS, probiotics, which can promote intestinal motility and correct and maintain the balance of flora, have been proven effective in the treatment of gastrointestinal diseases. AIM To investigate the therapeutic effects of microecological agents combined with metformin in patients with type 2 diabetes mellitus (T2DM) with IBS and their modulatory effect on the intestinal flora and the Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD8)/nuclear factor-κB (NF-κB) signaling pathway. METHODS Two hundred patients with T2DM with IBS treated at our hospital from August 2018 to August 2022 were selected and randomly divided into either a control group or an observation group, with 100 cases in each group. The control group was treated with metformin alone, and the observation group was treated with microecological agents combined with metformin. Intestinal sensitivity, intestinal flora (Lactobacillus, Bifidobacterium, Escherichia coli, and Enterococcus faecalis), short-chain fatty acids (SCFAs), blood glucose levels [fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), and 2-hour postprandial glucose (2hPG)], and serum levels of TLR4/MyD88/NF-κB signaling pathway-related proteins were compared between the two groups before and after treatment. The incidence of adverse effects was recorded.