Integrin β4 as a potential diagnostic and therapeutic tumor marker

Abstract

Integrin β4 (ITGβ4) is a class of transmembrane adhesion molecules composed of hemide-smosomes (HDs). Its unique long intracellular domain provides intricate signal transduction func-tions. These signal transduction effects are especially prominent in tumors. Many recent studies have shown that integrin β4 is differentially expressed in various tumors, and it plays a vital role in tumor invasion, proliferation, epithelial–mesenchymal transition, and angiogenesis. Therefore, we categorize the research related to integrin β4, starting from its structure and function in tumor tissues, and provide a basic description. Based on its structure and function, we believe that integrin β4 can be used as a tumor marker. In clinical practice, it is described as a diagnostic marker for the targeted treatment of cancer and will be helpful in the clinical diagnosis and treatment of tumors.