Cu-catalyzed asymmetric Michael addition of glycine derivatives to α,β-unsaturated malonates

Abstract

Michael addition of glycine imines with alkylidene and arylidene malonates has been developed using Cu/FcPhox as catalyst, providing corresponding Michael products in high yields with high diastereo- and enanti-oselectivities. © 2010 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.