Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

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Abstract

The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.

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APA

Hobson, J. J., Curley, P., Savage, A. C., Al-Khouja, A., Siccardi, M., Flexner, C., … Rannard, S. P. (2019). Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations. Nanoscale Advances, 1(11), 4301–4307. https://doi.org/10.1039/c9na00529c

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