Disposable chronoamperometric sensor for detecting ciprofloxacin

Abstract

The purpose of this study is to develop a disposable, inexpensive, and compact biosensor for rapid detection of ciprofloxacin (Cipro) in water. The electrochemical sensor used is a screen-printed electrode (SPE), and chronoamperometric (CA) method is used for detection of Cipro. Different concentrations of Cipro were tested for the response of the sensor, by the simple application of a droplet of Cipro at the working electrode of the SPE and measured the CAresponse for a particular applied voltage of 0.35 Vversus Ag/AgCl. From the CAanalysis and the linear regression analysis equation, we measured the sensitivity to be 0.031 μA μM-1. The limit of detection of the sensor was measured to be 0.33 μM, with a linear determination coefficient of .986, over a linear range of concentrations of Cipro (13.75 μM-135 μM).