Effects of fenoterol on ventilatory responses to hypoxia and hypercapnia in normal subjects

Abstract

Background - The effects of β2 adrenergic agonists on chemoreceptors remain controversial. This study was designed to examine whether fenoterol, a β2 adrenergic agonist, increases the ventilatory responses to hypercapnia (HCVR) and hypoxia (HVR) in normal subjects. Methods - HCVR was tested with a rebreathing method and HVR was examined with a progressive isocapnic hypoxic method in 11 normal subjects. Both HCVR and HVR were assessed by the slope of occlusion pressure (P0.1) or ventilation (V̇E) plotted against end tidal carbon dioxide pressure and arterial oxygen saturation, respectively. Respiratory muscle strength, spirometric values and lung volume were measured. After a single oral administration of 5 mg fenoterol or placebo HCVR and HVR were evaluated. Results - Fenoterol treatment did not change the specific airway conductance or forced expiraotyr volume in one second. Respiratory muscle strength did not change the specific airway conductance or forced expiratory volume in one second. Respiratory muscle strength did not change. Fenoterol increased the slope of the HCVR of both P0.1 (from 0.251 (0.116) to 0.386 (0.206) kPa/kPa, average increase 71%) and V̇E (from 10.7 (3.4) to 15.1 (4.2) l/min/kPa, average increase 52%), and shifted the response curves to higher values. For the HVR fenoterol increased the slopes of both P0.1 and V̇E (from -4.06 (2.00) x 10-3 to -7.99 (4.29) x 10-3 kPa/%, an average increase of 83%, and from -0.221 (0.070) to -0.313 (0.112) l/min/%, a 44.5% increase, respectively), and shifted the response curves to higher values. Conclusion - Acute administration of fenoterol increases the ventilatory responses to both hypercapnia and hypoxia in normal subjects.