Comparative study of Carica papaya with marketed product for the treatment of wounds in diabetic rodents

Abstract

Diabetes is an unending situation associated with peculiarly elevated levels of sugar (glucose) in the blood. This chronic illness is also related with the degenerative extended pathological disorders like retinopathies, nephropathies, atherosclerosis, wound healing problems and cataract. Insulin a hormone prepared by pancreas helps glucose from foodstuff get into your cells to be utilised for energy. Due to overtime the large amount of glucose in your body can results for health problem also. Tissue renovates and wound curing are complicated processes that engross inflammation, granulation and tissue remodelling. Wound curing is characterised by two stages via inflammation and proliferation. The extract of Carica Papaya fruit has been checked for its wound curing nature in streptozotocin induced diabetic rats by using excision as well as dead space wound models. The therapeutic utilisation of Carica Papaya relies because of the existence of papain an active constituent. Carica Papaya have antimicrobial, antioxidant and anti inflammatory behaviour which provoke us to ensure the wound curing property of following drugs on wound healing specially on diabetic rodent. This whole study emphasize on the effect of diabetes (high blood glucose sugar level) on the wound curing rate of rodents. Diabetes was induced by using streptozotocin and the blood glucose estimation was performed on tail vein blood by using a glucometer accu check wistar rats whose fasting blood glucose levels exceeded 250 mg/dl, were measured as diabetic.