Effect of paternal age on intracytoplasmic sperm injection outcomes in cryptozoospermic men Ejaculated or testicular sperm?

Abstract

It is not clear whether age has any influence on the outcomes for sperm used for assisted reproductive technology i cryptozoospermic men. We evaluated intracytoplasmic sperm injection (ICSI) outcomes using ejaculated or testicular sperm in me with cryptozoospermia from different paternal age ranges. We conducted a retrospective observational study of 35 men with cryptozoospermia who underwent ICSI from 2010 to 201 They were classified into 2 groups based on male age, namely < 35 years and ≥ 35 years. Each group was further divided into subgroups according to the origin of sperm (ejaculated or testicular). In the <35 years group, the normal fertilization and high-quality embryo rates for ejaculated sperm were significantly higher tha with testicular sperm (74.7% vs. 62.4%, P = .02; 50.5% vs. 36.6%, P = .03, respectively). However, in the ≥35 years group, the high quality embryo and clinical pregnancy rates were significantly lower in the ejaculated sperm subgroup than in the testicular sper subgroup (26.2% vs. 63%, P = .002; 12.5% vs. 71.4%, P = .04, respectively). This study indicates that ICSI should be performed as soon as possible for men with cryptozoospermia. When the paternal ag ≥35 years, testicular sperm should be used for ICSI, as this offers better high-quality embryo and clinical pregnancy rates.