Abstract
Background: Pgp3 is an immunogenic protein secreted by Chlamydia trachomatis. Results: The trimeric Pgp3 structure reveals globular domains connected by a triple helical coiled-coil. Conclusion: The C-terminal domains resemble tumor necrosis factor, the helical coiled-coil has an unusual twist, and the N-terminal domain is a fusion of virus-like structural motifs. Significance: The Pgp3 structure provides insight into its role in chlamydial pathogenesis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Galaleldeen, A., Taylor, A. B., Chen, D., Schuermann, J. P., Holloway, S. P., Hou, S., … Hart, P. J. (2013). Structure of the chlamydia trachomatis immunodominant antigen Pgp3. Journal of Biological Chemistry, 288(30), 22068–22079. https://doi.org/10.1074/jbc.M113.475012
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