Early Motor Fluctuations in a Patient with Striatonigral Degeneration

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Abstract

We report a 44-year-old female with striatonigral degeneration (SND) who showed wearing-off oscillations after 4 months of levodopa treatment. The patient presented with asymmetric left-side dominant rigidity, and levodopa was effective at first. However, she began to show wearing-off oscillations of motor symptoms, which gradually worsened thereafter. Fluid-attenuated inversion recovery sequence magnetic resonance imaging (MRI) showed linear lateral putamen hyperintensities, and positron emission tomography (PET) studies using 18F-fluorodopa (FD) and 11C-N-methylspiperon (NMSP) showed a marked decrease of radioactivity in the right putamen, especially in the posterior putamen. The results of MRI and 2 PET studies with FD and NMSP were well consistent with the diagnosis of SND.

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Yoshii, F., Moriya, Y., Ohnuki, T., Takahashi, W., & Ryo, M. (2016). Early Motor Fluctuations in a Patient with Striatonigral Degeneration. Case Reports in Neurology, 8(3), 243–250. https://doi.org/10.1159/000453254

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