Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer's disease mice model

Abstract

Introduction: Alzheimer disease is the most common form of dementia and it has been characterized by histopathological hallmarks, as senile plaques and neurofibrillary tangles. In addition, to a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators, such as IL-1Β, iNOS and COX-2, leading to neuronal dysfunction and death. Objective: We evaluated the effect of quercetin on the inflammatory response in the CA1 area of the hippocampus from a 3xTg-AD male and female mice model. Materials and methods: Animals were injected intraperitoneally with quercetin (Qc) each to 48 hours during three months, histological and biochemical studies were realized. Results: In this study we found that 3xTg-AD after Qc-treatment significantly decreased reactive microglia and the fluorescence intensity of Aß aggregates; accompanied by decreased GFAP, iNOS and COX-2 immunoreactivity and a clear tendency in the reduction of IL-1Β in hippocampal lysates. Conclusion: Our work suggests an anti-inflammatory effect of quercetin in the CA1 hippocampal region of aged triple transgenic Alzheimer's disease mice.