Recent aspects of glycoconjugate synthesis: A synthetic approach to the linkage region of proteoglycans*

Abstract

A versatile synthetic route to nonsulfated, as well as mono and disulfated glycohexaosyl serines that correspond to the linkage region of proteoglycans is developed by employing a glycotriaosyl donor and a glycotriaosyl acceptor Chemoselective removal of levuloyl groups among other ester groups without causing any acyl migration was carried out and subsequent regiospecific introduction of sulfate groups was achieved successfully. © 1993 IUPAC