Uncommon metastatic site from breast cancer

Abstract

Introduction. Breast cancer is one of the most common malignancies in women and the main leading cause of cancer death. The most frequent sites of metastases from breast cancer are bones, lungs, the central nervous system, the liver and soft tissue. Colonic metastases from breast cancer are rare. Case report. We presented a 70-year-old woman with bulky obstructing lesion of sigmoid colon. A physician in charge on our department examined the patient and past history of breast cancer was found up. Surgery was performed with removal of sigmoid colon and three of six lymph nodes were positive. Pathological examination, including immunohistochemical stains, confirmed the diagnosis of metastatic breast cancer to sigmoid colon. The multidisciplinary oncology team suggested postoperative chemotherapy. The patient received four cycles of chemotherapy with paclitaxel followed by anastrozole. On the first control visit no disease activity was detected. Conclusion. In patients with the past history of breast cancer the symptoms of hematochezia or anemia may indicate colonic metastases.Uvod. Karcinom dojke jedan je od najcescih karcinoma kod zena i vodeci uzrok smrti od malignih bolesti. Karcinom dojke najcesce metastazira u kosti, pluca, centralni nervni sistem i jetru. Metastaze u debelo crevo su jako retke. Prikaz bolesnika. Prikazali smo bolesnicu, staru 70 godina, sa dijagnozom opstruktivne infiltracije sigmoidnog dela kolona. Lekar koji je pregledao bolesnicu dobio je podatak da je bolesnica operisala karcinom dojke. Bolesnica je operisana, uradjena je resekcija sigmoidnog dela kolona, i od pregledanih sest limfnih cvorova u tri su se nalazila zarista metastaza. Patoloskohistoloskim pregledom, ukljucujuci imunohistohemijsku analizu, potvrdjena je dijagnoza metastatskog karcinoma dojke u sigmoidni kolon. Multidisciplinarni onkoloski tim predlozio je postoperativnu hemioterapiju. Bolesnica je primila cetiri ciklusa hemioterapije sa paklitakselom i nakon toga nastavila terapiju anastrazolom. Na prvom kontrolnom pregledu nisu vidjeni znaci aktivnosti maligne bolesti. Zakljucak. Kod bolesnica sa ranije postavljenom dijagnozom karcinoma dojke, sa simptomatologijom krvi u stolici ili prisutnom malokrvnoscu treba misliti i na mogucnost pojave metastaza karcinoma dojke u debelo crevo.