Inhibitory effects of 4-guanidinobutyric acid against gastric lesions

Abstract

This study examined the inhibitory effects of 4-guanidinobutyric acid (4GBA), an alkaloid, against gastric lesions by assessing the inhibition of Helicobacter ylori (H. ylori) and gastric cancer cells. Acute and chronic gastritis were also observed using HCl/ ethanol (EtOH) and indomethacin-induced gastric lesion models, res ectively. 4GBA inhibited the growth of H. ylori in a dose de endent manner, and showed acid-neutralizing ca acity. In the ylorus ligated rats, 4GBA decreased the volume of gastric secretion and gastric acid out ut slightly, and increased the H. 4GBA at a dose of 100 mg/kg reduced the size of HCl/EtOH-induced gastric lesions (70.8%) and indomethacin-induced gastric lesions (38.8%). The antigastritic action of 4GBA might be associated with the acid-neutralizing ca acity, anti-H. ylori action, and decreased volume of gastric secretion. These results suggest that 4GBA might be useful in the treatment and/or rotection of gastritis. © 2012 The Korean Society of Applied Pharmacology.