Peripheral Neuropathy and Indomethacin

Abstract

A patient with seronegative inflammatory polyarthritis developed a predominantly motor peripheral neuropathy associated with the use of indomethacin. Three other cases of peripheral neuropathy associated with indomethacin treatment have been reported to the Committee on Safety of Medicines. In all cases the neuropathy regressed when indomethacin was stopped. Peripheral neuropathy should be recognized as a rare complication of indomethacin therapy and considered in the differential diagnosis of a neuropathy accompanying rheumatoid arthritis. © 1975, British Medical Journal Publishing Group. All rights reserved.