Preparation, characterization and properties of porous PLA/PEG/curcumin composite Nanofibers for antibacterial application

Abstract

Polylactide/polyethylene glycol/curcumin (PLA/PEG/Cur) composite nanofibers (CNFs) with varying ratios of PEG were successfully fabricated by electrospinning. Characterizations of the samples, such as the porous structure, crystalline structure, pore size, wetting property and Cur release property were investigated by a combination of scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and UV spectrophotometer. The antibacterial properties of the prepared porous CNFs against Escherichia coli bacteria were studied. The results showed that with the decrease of PEG in the CNFs, there appeared an evident porous structure on the CNF surface, and the porous structure could enhance the release properties of Cur from the CNFs. When the weight ratio (PEG:PLA) was 1:9, the pore structure of the nanofiber surface became most evident and the amount of Cur released was highest. However, the antibacterial effect of nonporous CNFs was better due to burst release over a short period of time. That meant that the porous structure of the CNFs could reduce the burst release and provide better control over the drug release.