Prognostic value of proton magnetic resonance spectroscopy findings in near drowning patients: Reversibility of the early metabolite abnormalities relates with a good outcome

Abstract

In two children with near drowning hypoxic encephalopathy and normal-appearing structural MRI, acute proton magnetic resonance spectroscopy (1H MRS) showed biochemical alterations that correctly indicated prognosis and helped to guide management decisions. Elevation of the lipid-lactate and glutamine-glutamate peaks, on the early (72 hour) 1H MRS, predicts a poor prognosis. Absence of lipid-lactate and glutamine-glutamate peaks on the early 1H MRS and reversibility of early mild metabolite abnormalities on follow up examination relates with good outcome.