Evaluation of in vitro antidiabetic and antioxidant potential of Barleria cristata leaves extracts

Abstract

Objectives: The objectives of the study were to study the in vitro antidiabetic and antioxidant activity of Barleria cristata leaves extracts. Methods: Ethanol extract and petroleum ether extract of leaf and root of B. cristata were tested for their antidiabetic activity. The in vitro antidiabetic activity from α-amylase, α-glucosidase, and antioxidant activity was used to assess the potential activity of the fractions. Results: Our attempt results suggest that ethanol and the petroleum ether leaf extract from B. cristata show signs of dose-dependent increases to inhibitory activity on α-amylase, α-glucosidase enzymes, and antioxidant activity when compared with control. Ethanolic leaves to extract produced maximum in vitro antidiabetic effect and antioxidant activity when compared to petroleum ether extract. Conclusion: The ethanol leaf extract from B. cristata may be used in managing of blood glucose in a medical condition like diabetes.