Physical aging of polylactide-valsartan system investigated by differential scanning calorimetry

Abstract

The polylactide-valsartan systems with a mass ratio of 20: 80, 50: 50 and 80: 20 were obtained and characterized by standard Differential Scanning Calorimetry (DSC). The isothermal physical aging process of polylactide-valsartan with a mass ratio of 50: 50 was investigated at the aging temperature of 50°C and 70°C for different aging times. The enthalpy of relaxation values for each of the aging times and for all investigated components were determined experimentally and fitted to the Kohlrausch-Williams-Watts equation.