Efficacy of Trichloroacetic Acid (TCA) Compared to Cryotherapy in Treating Patients with Positive IVA Result

Abstract

Objective: To investigate the effectiveness TCA 85% compared to cryotherapy to treat patients with positive IVA result. Methods: This is a non-inferiority randomized controlled trial study. Patients with positive VIA result referred to Jatinegara Primary Health Center were included in this study. Eligible samples were then treated with either TCA 85% or cryotherapy. The treatment was determined using a random block sampling method. Samples were then followed up 3 months after treatment in order to determine VIA result conversion. Results: Thirty-six patients were treated with TCA 85% and 36 others were treated with cryotherapy. 35 (97,2%) patients treated with TCA 85% converted to negative VIA, whereas all of the patients that were treated with cryotherapy converted to negative VIA. Bivariate analysis fisher’s exact test was then conducted with a result P-value of 1.00 (p > 0,05). Conclusions: There was no statistically significant difference of result between TCA 85% and cryotherapy for treating patients with positive VIA result.