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A novel self-adjuvanted mRNA vaccine expressing the Antigen-85B-p25 epitope of Mycobacterium tuberculosis protects mice against tuberculosis

  • Mishra A
  • Singh V
  • Court K
  • et al.
The Journal of Immunology (2023) 210(Supplement_1) 141.03-141.03
DOI: 10.4049/jimmunol.210.supp.141.03
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Abstract

Mycobacterium tuberculosis (Mtb) is a leading cause of death due to infections. BCG is the most used vaccine despite having partial efficacy against the tuberculosis. We have developed a synthetic mRNA vaccine, SelmRp25-C5, which expresses the p25 epitope of Mtb-derived Antigen-85B and a TLR-2 stimulating C5 adjuvant peptide from CFP-10 protein. We evaluated its efficacy both ex vivo and in mice.

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APA

Mishra, A., Singh, V., Court, K. P., Godin, B., Sukhovershin, R., Kiss, D., … Jagannath, C. (2023). A novel self-adjuvanted mRNA vaccine expressing the Antigen-85B-p25 epitope of Mycobacterium tuberculosis protects mice against tuberculosis. The Journal of Immunology, 210(Supplement_1), 141.03-141.03. https://doi.org/10.4049/jimmunol.210.supp.141.03

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