Inflammasome-independent functions of AIM2

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Abstract

AIM2 is widely known for its role as a cytosolic dsDNA receptor that activates the inflammasome. In this issue of JEM, Ma et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201796) describe an inflammasome-independent function of AIM2 in microglia that restrains neuroinflammation via a novel crosstalk between AIM2 and cGAS signaling.

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Zhao, J., Miller-Little, W., & Li, X. (2021, April 9). Inflammasome-independent functions of AIM2. Journal of Experimental Medicine. Rockefeller University Press. https://doi.org/10.1084/jem.20210273

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