Recent developments in palladium-catalyzed oxidations

Abstract

The palladium-catalyzed intramolecular 1,4-oxidation of conjugated dienes has been extended to carbon-carbon bond formation. Two different methods were developed. In the first method, a vinylpalladium intermediate is generated in the side chain which adds to the diene. In the other method an allylsilane is used as nucleophile in the side chain. The first type of reaction leads to a 1,4-anti addition of carbon and a chloride and the second to a 1,4-syn addition of carbon and chloride to the 1,3-diene. © 1996, Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.