Synthesis and dopamine receptor binding of some pyrazolo[3′,4′:6,7]azepino[5,4,3-cd]indoles

Peter Gmeiner; Harald Hübner; Kayed A. Abu Safieh; Ismail I. Fasfous; Mustafa M. El-Abadelah; Salim S. Sabri; Wolfgang Voelter

Journal Article

Synthesis and dopamine receptor binding of some pyrazolo[3′,4′:6,7]azepino[5,4,3-cd]indoles

Heterocycles (2003) 60(6) 1339-1350

DOI: 10.3987/com-03-9734

10Citations

1Readers

Get full text

Abstract

A synthesis of some substituted pyrazolo[3′,4′:6,7]azepino[5,4,3-cd]indoles is described and their affinities to dopamine receptors were evaluated. The tested compounds (3a-d and 4a,b) showed micromolar affinity to the bovine D1 receptor subtype and the human D2, D3 and D4 receptor isoforms.

Cite

CITATION STYLE

APA

Gmeiner, P., Hübner, H., Abu Safieh, K. A., Fasfous, I. I., El-Abadelah, M. M., Sabri, S. S., & Voelter, W. (2003). Synthesis and dopamine receptor binding of some pyrazolo[3′,4′:6,7]azepino[5,4,3-cd]indoles. Heterocycles, 60(6), 1339–1350. https://doi.org/10.3987/com-03-9734

Synthesis and dopamine receptor binding of some pyrazolo[3′,4′:6,7]azepino[5,4,3-cd]indoles

Abstract

Cite

Register to see more suggestions