Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.
CITATION STYLE
Wallner, S., Peters, S., Pitzer, C., Resch, H., Bogdahn, U., & Schneider, A. (2015, August 7). The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity. Frontiers in Cell and Developmental Biology. Frontiers Media S.A. https://doi.org/10.3389/fcell.2015.00048
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