The efficacy of antimicrobial treatment in children with acute otitis media remains controversial.
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Tähtinen, P. A., Laine, M. K., Huovinen, P., Jalava, J., Ruuskanen, O., & Ruohola, A. (2011). A Placebo-Controlled Trial of Antimicrobial Treatment for Acute Otitis Media. New England Journal of Medicine, 364(2), 116–126. https://doi.org/10.1056/nejmoa1007174