Clinical valuation of ST changes in a group of patients with ventricular arrhythmias: The inSighT Study

Abstract

Background: The inSighT study was designed to determine the prevalence of ischemic changes as recorded by implantable cardioverter–defibrillator (ICD) ST deviations in intracardiac electrocardiograms (EGM) over the 24 h preceding malignant ventricular arrhythmias (VT/VF). Methods: The study enrolled patients with known coronary artery disease (CAD) or high risk of future development of CAD implanted with an ICD equipped with an ST monitoring feature (Ellipse™/Fortify Assura™, St. Jude Medical). Device session records were collected at each in-clinic follow-up. EGM ST levels of the beats over the 15 minutes prior to VT/VF events were compared using a t test with those from a baseline period of 23–24 h prior to the VT/VF event. All events with p