Genetic variability within Trypanosoma brucei gambiense: Evidence for the circulation of different genotypes in human African trypanosomiasis patients in Côte d'Ivoire

Abstract

For 23 Ivoirian patients infected by Trypanosoma brucei gambiense, isolation and genetic characterization using PCR and microsatellite primers were performed (in 1996-99) using 2 different isolates (A and B) from each patient. When using TBDAC 1/2, 7 genotypes were observed, and DNAs A and B for 2 patients were different. This might be the first evidence of the presence of 2 different genotypes of T. b. gambiense group 1 in the same patient.