Effect of Salix alba barks on experimentally induced obesity in rats

Abstract

Obesity is a multifactorial cradle that grows from the interaction of metabolic, cellular, molecular, psychological, behavioral and social factors. This condition characterized by increasing in content and size of adipose tissue, and fat accumulation, leading to an increment in the weight of the body. The objective of the present study is to investigate the effects of Salix alba barks as herbal medicine on body weight parameters, lipid profiles, and metabolic inflammation in rats' experimental models of obesity. In the current study, we used forty apparently healthy Wister male rats were involved in the present study, divided into four groups. Obesity was induced by the administration of high-fat diets for 8 weeks to stimulate adiposity. The first group received a normal diet with a daily dose of distilled water intraperitoneally and left without treatment and considered as a control group. The remaining three groups that were induced to be obese, received (Orlistat 35 mg/kg and Salix alba 150mg/kg) after the induction period for 28 days, except one group left without treatment. The blood was collected from all animal groups, and then serum obtained for the biochemical analysis. Our results showed that in obese animals, body weight and body mass index were significantly reduced by Salix alba after 4 weeks of treatment. Fasting cholesterol, TG, LDL, VLDL, TNFa, and visfatin and leptin were significantly decreased, while HDL, IL10, and adiponectin significantly elevated by Salix alba compared with HFD induced obese animal group. To conclude, Salix alba barks improve lipid profile as well as reducing the elevated body weight. Salix alba barks inhibit metabolic inflammatory response associated with obesity. The adipose tissue-derived adipokines were got better with this herb.