Intestinal ischemia-reperfusion (I/R) causes severe organ failure and intense inflammatory responses, which are mediated in part by the cytokine tumor necrosis factor-alpha (TNF-alpha). Bupropion is an antidepressant known to inhibit TNF-alpha production. We sought to examine the protective effects of bupropion on intestinal I/R injury in 15 male Sprague-Dawley rats that were randomized to sham surgery, 45 minutes of intestinal ischemia followed by 180 minutes reperfusion, or bupropion (100 mg/kg) before the intestinal I/R injury. To evaluate the systemic inflammatory response induced by intestinal I/R, we measured serum levels of TNF-alpha, interleukins-1 and -6, lipid peroxidation, and transaminases. Histologic analysis evaluated intestinal injury using the Chiu muscosal injury score. After I/R, Chiu score in control animals was 3.6 ± 1.2 vs 2.6 ± 0.53 in animals that received bupropion (P
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Cámara-Lemarroy, C. R., Guzmán-De La Garza, F. J., Cordero-Pérez, P., Alarcón-Galván, G., Ibarra-Hernández, J. M., Muñoz-Espinosa, L. E., & Fernández-Garza, N. E. (2013). Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion. Transplantation Proceedings, 45(6), 2502–2505. https://doi.org/10.1016/j.transproceed.2013.04.010
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