Impact of gender on long-Term outcomes after surgical repair for acute Stanford A aortic dissection: A propensity score matched analysis

Abstract

OBJECTIVES: Previous research suggests that female gender is associated with increased mortality rates after surgery for Stanford A acute aortic dissection (AAD). However, women with AAD usually present with different clinical symptoms that may bias outcomes. Moreover, there is a lack of long-Term results regarding overall mortality and freedom from major cerebrovascular events. We analysed the impact of gender on long-Term outcomes after surgery for Stanford A AAD by comparing genders with similar risk profiles using propensity score matching. METHODS: A total of 240 patients operated for Stanford A AAD were included in this study. To control for selection bias and other confounders, propensity score matching was applied to gender groups. RESULTS: After propensity score matching, the gender groups were well balanced in terms of risk profiles. There were no statistically significant differences regarding duration of cardiopulmonary bypass (P = 0.165) and duration of aortic cross-clamp time (P = 0.111). Female patients received less fresh frozen plasma (P = 0.021), had shorter stays in the intensive care unit (P = 0.031), lower incidence of temporary neurological dysfunction (P < 0.001) and lower incidence of dialysis (P = 0.008). There were no significant differences regarding intraoperative mortality (P = 1.000), 30-day mortality (P = 0.271), long-Term overall cumulative survival (P = 0.954) and long-Term freedom from cerebrovascular events (P = 0.235) with up to a 9-year follow-up. CONCLUSIONS: Considering patients with similar risk profiles, female gender per se is not associated with worse long-Term survival and freedom from stroke after surgical aortic repair. Moreover, female patients might even benefit from a smoother early postoperative course and lower incidence of early postoperative complications.