Four new doramectin congeners with acaricidal and insecticidal activity from streptomyces avermitilis NEAU1069

Abstract

Four new doramectin congeners, 1-4, were isolated from Streptomyces avermitilis NEAU1069. The structures of 1-4 were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS, ESI-MS, UV, and IR, and comparison with literature data. All compounds exhibited noticeable acaricidal and insecticidal activities. Especially compound 2 was found to be the most potent pesticide of the compounds evaluated with the IC 50 values of 10.2, 65.1 and 124.4μg/ml against adult two-spotted spider mites (Tetranychus urticae Koch), two-spotted spider mite eggs, and Mythimna separata, respectively, which are comparable to those of commercial pesticide milbemycin A 3/A 4 as positive reference. © 2011 Verlag Helvetica Chimica Acta AG, Zürich.