Abstract
Sixteen patients, 15 adults and one child, with APL have been studied cytogenetically; 14 of these had an abnormal karyotype (87%). Eleven of these consistently showed a t(15;17)(q26;q22) structural anomaly, one patient showed a 47,+8 karyotype, one a rearrangement of chromosomes #15 and #17, apparently different from that in the other patients, and one a #17 deletion without a demonstrable translocation. As an additional chromosome change trisomy #8 was found in 5 cases and monosomy #7 in two. The t(15;17)(q26;q22) structural anomaly is highly characteristic of APL, is found in APL of children and adults, but it is apparently not associated with a clinically different form of APL. Cancer 43:558–562, 1979. Copyright © 1979 American Cancer Society
Cite
CITATION STYLE
Van Den Berghe, H., Louwagie, A., Van Orshoven, A. B., David, G., Verwilghen, R., Michaux, J. L., & Sokal, G. (1979). Chromosome abnormalities in acute promyelocytic leukemia (APL). Cancer, 43(2), 558–562. https://doi.org/10.1002/1097-0142(197902)43:2<558::AID-CNCR2820430223>3.0.CO;2-6
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