Synthesis of sepiapterin-C via hydrolysis of 6-ethynylpteridine

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Abstract

Acid hydrolysis of 6-ethynylpteridine catalyzed by mercury oxide gives 6-acetyl-2-amino-3,4-dihydropteridin-4-one in good yield. Partial reduction of the product with dissolved Al in NH3 solution afforded sepiapterin-C.

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Nxumalo, W., & Dinsmore, A. (2014). Synthesis of sepiapterin-C via hydrolysis of 6-ethynylpteridine. Natural Product Communications, 9(1), 37–38. https://doi.org/10.1177/1934578x1400900112

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