Abstract
(Figure Presented) Quicker and slicker: An efficient metalfree 1,3-dipolar cycloaddition of dibenzocyclooctynes with nitrones proceeded with rate constants of up to 39 M-1S-1, or up to 300 times faster than similar reactions with azides. This strategy is useful for the site-specific N-terminal modification of peptides and proteins (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
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Ning, X., Temming, R. P., Dommerholt, J., Guo, J., Ania, D. B., Debets, M. F., … Van Delft, F. L. (2010). Protein modification by strain-promoted alkyne-nitrone cycloaddition. Angewandte Chemie - International Edition, 49(17), 3065–3068. https://doi.org/10.1002/anie.201000408
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