Acute reversible renal failure in G-6 PD-deficient siblings

Abstract

Two G-6 PD-deficient siblings, who initially presented with intravascular haemolysis, and later developed acute oliguric renal failure, are described. Renal failure reversed as haemolysis regressed in both patients. The pathogenesis of this complication is reported to be multifactorial but in our patients tubular obstruction by haemoglobin casts is the most probable mechanism. The importance of recognizing this renal complication in G-6 PD-deficient subjects is stressed.