Sleep deprivation in the rat: XIV. Comparison of waking hypothalamic and peritoneal temperatures

Abstract

Earlier studies of rats subjected to total sleep deprivation (TSD) by the disk-over-water method had shown an initial increase in waking peritoneal temperature (T(ip)) followed by an even greater decrease as deprivation proceeded. In the present study, hypothalamic temperature (T(hy)), as well as T(ip), were recorded continuously. As in the earlier studies, TSD rats showed an increase in energy expenditure and an initial increase followed by a decrease in T(ip). Waking T(hy) showed a more prolonged initial rise and a smaller late decline than waking T(ip). Assuming that, as the literature suggests, T(hy) is held closer to temperature setpoint (T(SET)) than is T(ip), the present results suggest an elevated waking T(SET) during deprivation. T(ip) became progressively lower than T(hy) over the course of deprivation, indicating a decreased ability to maintain the whole body near T(SET). This decreased ability could result from insufficient thermogenesis or excessive heat loss. Because thermogenesis rose progressively throughout deprivation, heat loss must have increased even more than heat production. Thus, the results are consistent with other data which indicate that TSD in the rat produces two opposing effects on waking temperature, an elevation of setpoint and excessive heat loss, which together increase the demand for energy expenditure.