Iridium-Catalyzed Enantioselective Allylic Vinylation with Potassium Alkenyltrifluoroborates

Abstract

The first example of Ir-catalyzed asymmet- ric substitution reaction with vinyl trifluoroborates is described. The direct reaction between branched, racemic allylic alcohols and potassium alkenyl-trifluoroborates proceeded with high site selectivity and excellent enantioselectivity (up to 99%) mediated by an Ir-(P,olefin) complex. This method allows rapid access to various 1,4- dienes or trienes including the biologically active natural products (−)-nyasol and (−)-hinokiresinol.