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Magnetic sensors for protease assays

Angewandte Chemie - International Edition (2003) 42(12) 1375-1378
DOI: 10.1002/anie.200390352
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Abstract

Superparamagnetic nanosensors conjugated to avidin (CLIO-A) can be used to measure sensitively and quantitively the proteolytic cleavage of bi-biotinylated peptide substrates (rods in the scheme) by changes in magnetic resonance properties. This approach may be generalized to determine the activity of a wide range of hydrolytic enzymes.

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Zhao, M., Josephson, L., Tang, Y., & Weissleder, R. (2003). Magnetic sensors for protease assays. Angewandte Chemie - International Edition, 42(12), 1375–1378. https://doi.org/10.1002/anie.200390352

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