Use of N im - t -Butyloxycarbonyl in the Synthesis of Poly- L -histidine

Abstract

N α ,N im- -Di-t-butyloxycarbonyl-L-histidine, N α -benzyloxycarbonyl- N im -t-butyloxycarbonyl-L-histidine and poly- L-histidine have been synthesized. The role in peptide synthesis of t-butyloxycarbonyl as an imidazole-blocking group is discussed and compared to other currently available imidazole-blocking groups.